Article

The neuronal homeobox transcription factor HMX3 is a crucial vulnerability factor in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia

2023-11-09

Abstract excerpt

The KMT2A::MLLT3 fusion protein causes acute myeloid leukemia (AML) by activating the oncogenic transcription factor MECOM. However, MECOM expression occurs in only half of the KMT2A::MLLT3 cases. By integrating gene expression and enhancer activity data from patient cells, we identified neuronal homeobox transcription factor HMX3 as cell fate determining factor in MECOM -negative KMT2A::MLLT3 AML. HMX3 expres...

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Literature Corpus work: 7655558c-310f-56f0-97ca-3bb30499e3d5
DOI: 10.1101/2023.11.07.565950

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