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Organoid-evaluable clinical biomarkers predict drug responses and guide new breast cancer therapies

2025-08-28

Abstract excerpt

Poor therapeutic response in subsets of breast cancer (BC) patients poses an ongoing challenge. Here, we present a biomarker-guided characterization of 44 patient-derived BC organoids, with the aim of modeling resistant disease with greater fidelity and developing an in-vitro system grounded in clinical data for testing alternative treatment strategies. We utilized patient transcriptomic and outcome data from the...

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Literature Corpus work
9103cdd6-2e68-5070-a3b9-c9165e4cbc54
DOI
10.1101/2025.08.24.671810
Open publication

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Organoid-evaluable clinical biomarkers predict drug responses and guide new breast cancer therapiesDOI 10.1101/2025.08.24.671810
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