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Article

Biomarker-Driven Early Clinical Trials in Oncology

1 Sept 2009

Abstract excerpt

Early clinical trials represent a crucial bridge between preclinical drug discovery and the especially resource-intense randomized phase III trial-the definitive regulatory hurdle for drug approval. High attrition rates and rising costs, when coupled with the extraordinary opportunities opened up by cancer genomics and the promise of personalized medicine call for new approaches in the conduct and design of phase...

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PMID: 19826361
DOI: 10.1097/ppo.0b013e3181bd0445

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