Article

GM-CSF signaling is critical for HER2+ breast leptomeningeal carcinomatosis

2020-09-09

Abstract excerpt

<title>Abstract</title> <p>Leptomeningeal carcinomatosis (LC), when tumor cells spread to leptomeninges surrounding the brain and spinal cord. HER2+ breast cancer is the most common origin of LC. HER2+ LC remains incurable, with few treatment options and response rates of <20%. One major limitation in development of HER2+ LC therapies has been lack of clinically relevant HER2+ LC primary cell-lines and animal mod...

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Literature Corpus work: 7648447a-9698-5cf1-bbc9-9fe321d03691
DOI: 10.21203/rs.3.rs-65694/v1

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