Article
A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma.
Cancer research - 1 Dec 2020
Tateishi Kensuke, Miyake Yohei, Kawazu Masahito, Sasaki Nobuyoshi, Nakamura Taishi, Sasame Jo, Yoshii Yukie, Ueno Toshihide, Miyake Akio, Watanabe Jun, Matsushita Yuko, Shiba Norio, Udaka Naoko, Ohki Kentaro, Fink Alexandria L, Tummala Shilpa S, Natsumeda Manabu, Ikegaya Naoki, Nishi Mayuko, Ohtake Makoto, Miyazaki Ryohei, Suenaga Jun, Murata Hidetoshi, Aoki Ichio, Miller Julie J, Fujii Yukihiko, Ryo Akihide, Yamanaka Shoji, Mano Hiroyuki, Cahill Daniel P, Wakimoto Hiroaki, Chi Andrew S, Batchelor Tracy T, Nagane Motoo, Ichimura Koichi, Yamamoto Tetsuya
Abstract excerpt
Primary central nervous system lymphoma (PCNSL) is an isolated type of lymphoma of the central nervous system and has a dismal prognosis despite intensive chemotherapy. Recent genomic analyses have identified highly recurrent mutations of MYD88 and CD79B in immunocompetent PCNSL, whereas LMP1 activation is commonly observed in Epstein-Barr virus (EBV)-positive PCNSL. However, a lack of clinically representative...
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