Article

Targeted Therapy Decision in HER2 Exon 20–Mutant Non-Small Cell Lung Cancer with Leptomeningeal Disease: A Case-Based Perspective

2025-06-27

Abstract excerpt

<title>Abstract</title> <p>We report a rare and clinically challenging case of leptomeningeal disease (LMD) secondary to HER2-mutated non-small cell lung cancer (NSCLC), marked by both exon 20 insertion and gene amplification. In the absence of LMD-specific therapeutic guidelines for HER2-driven NSCLC, we initiated treatment with trastuzumab deruxtecan (Enhertu), based on extrapolated evidence from clinical trial...

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Literature Corpus work: 5a39180f-6944-5f7d-84d5-6981f114dffc
DOI: 10.21203/rs.3.rs-6925753/v1

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