Article

Distinct medical and substance use histories associate with cognitive decline in Alzheimer’s Disease

2024-11-28

Abstract excerpt

<h4>INTRODUCTION</h4> Phenotype clustering reduces patient heterogeneity and could be useful when designing precision clinical trials. We hypothesized that the onset of early cognitive decline in patients would exhibit variance predicated on the clinical history documented prior to an Alzheimer’s Disease (AD) diagnosis <h4>METHODS</h4> Self-reported medical and substance use history (i.e., problem history) was use...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7641e0bb-bcb9-5ae4-9a06-3b95d42449e5
DOI: 10.1101/2024.11.26.24317918

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct medical and substance use histories associate with cognitive decline in Alzheimer’s DiseaseDOI 10.1101/2024.11.26.24317918Read

Heterogeneity of Alzheimer’s disease: consequence for drug trials?Semantic proximity Read

Identifying incident dementia by applying machine learning to a very large administrative claims datasetSemantic proximity Read

Comparative Mortality Risk of Aripiprazole, Olanzapine, Quetiapine and Risperidone in Alzheimer’s Disease: A Real□World Cohort Study with Treatment Effect Heterogeneity AnalysisSemantic proximity Read

Medication Exposure and Neurodegenerative Disease Risk Across National BiobanksSemantic proximity Read

The association between type 2 diabetes disease trajectories and dementia incidenceSemantic proximity Read

Utilizing Electronic Medical Records Identifies Similarities and Differences in Alzheimer’s Disease Comorbidities Between Racialized PopulationsSemantic proximity Read

Temporal Cohort Identification for Alzheimer’s Disease with Sequences of Clinical RecordsSemantic proximity Read

Relationships between alcohol use and dementia: protocol for an observational study in the UK Clinical Practice Research DatalinkSemantic proximity Read

A FinnGen pilot clinical recall study for Alzheimer’s diseaseSemantic proximity Read

Brain Multi-Omic Subtypes of Neuroticism reveal molecular signatures linked to Alzheimer’s DiseaseSemantic proximity Read

Neuropsychiatric symptom phenotypes for early detection of risk in older adults.Semantic proximity Read

Functional-vs-Cognitive Decline Heterogeneity in Alzheimer’s Disease: LLM-Curation of Decades of Clinical Notes and GLP1RA Trial DesignSemantic proximity Read