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Article

Neuropsychiatric symptom phenotypes for early detection of risk in older adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2025

Erani Fareshte, Terao Caitlin M, Cooper Shanna, Weigand Alexandra J, Bangen Katherine J, Edmonds Emily C, Coughlin David G, Thomas Kelsey R

Abstract excerpt

INTRODUCTION: We examined whether early neuropsychiatric symptom (NPS) patterns were associated with cognitive and neuropathologic changes. METHODS: Latent class analysis within 20,599 cognitively unimpaired older adults in the National Alzheimer's Coordinating Center dataset identified NPS phenotypes. Progression to cognitive impairment, cognitive trajectories, and neuropathology across phenotypes were assessed....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41216845
DOI: 10.1002/alz.70869
PMCID: PMC12603784

Genes

NPS

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