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Article

Heterogeneity of Alzheimer’s disease: consequence for drug trials?

1 Dec 2018

Abstract excerpt

BACKGROUND: Alzheimer's disease is a heterogenous disorder with multiple phenotypes and genotypes, although they eventually converge to a final common clinicopathological endpoint. However, Alzheimer's disease drug trials do not account for the heterogeneity of the disease in trial design, impeding development of effective drugs. DISCUSSION: Alzheimer's disease drug trials commonly have wide inclusion criteria...

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PMID: 30567585
DOI: 10.1186/s13195-018-0455-y

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