Article

Functional-vs-Cognitive Decline Heterogeneity in Alzheimer’s Disease: LLM-Curation of Decades of Clinical Notes and GLP1RA Trial Design

2026-06-09

Abstract excerpt

EVOKE and EVOKE+ trials showed no population-level slowing of early symptomatic Alzheimer’s disease (AD) with semaglutide, motivating an assessment of whether clinical-note phenotyping over decades of routine care could identify distinct AD trajectories. Here we analyzed de-identified EHRs from a 29 million-patient federated network using LLMs to extract standardized cognitive, functional, global severity, and neu...

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Literature Corpus work: 34261823-bd6b-541b-a77d-d9196e10c8a6
DOI: 10.20944/preprints202606.0711.v1

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Functional-vs-Cognitive Decline Heterogeneity in Alzheimer’s Disease: LLM-Curation of Decades of Clinical Notes and GLP1RA Trial DesignDOI 10.20944/preprints202606.0711.v1Read

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