Self-amplifying mRNA expression is governed by mitochondrial machinery and ACSL4

Abstract excerpt

<h4>ABSTRACT</h4> RNA-based vaccines offer a superior efficacious and economic approach over traditional vaccines. However, current dose requirement and short half-life of conventional modified mRNA (modRNA) may hinder the development of more effective vaccines. Self-amplifying mRNA (saRNA) is a modality that has the potential to address these limitations by reducing delivery dosage and enhancing the duration of...

Topics

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• CRISPR and Genetic Engineering
• Neurogenetic and Muscular Disorders Research
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• SARS-CoV-2 and COVID-19 Research
• Viral gastroenteritis research and epidemiology
• Viral Infections and Immunology Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

763e9057-37e6-5204-9a42-a4c589a224a4

DOI

10.1101/2025.06.13.659366