Article

Circulating Brevican and Neurocan Are Reduced in Alcohol Use Disorder: A Peripheral Signature of Perineuronal Nets Alterations

2026-07-27

Abstract excerpt

<title>Abstract</title> <p>Perineuronal nets (PNNs) are specialized extracellular matrix structures that stabilize synaptic connections and regulate neuroplasticity in brain circuits involved in reward, cognition, and impulse control. Brevican (BCAN) and neurocan (NCAN), two key chondroitin sulfate proteoglycans of PNNs, may serve as peripheral indicators of CNS matrix integrity. We measured plasma BCAN and NCAN...

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Literature Corpus work: b29bc699-6529-58c0-a733-5903410ce824
DOI: 10.21203/rs.3.rs-10436389/v1

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Circulating Brevican and Neurocan Are Reduced in Alcohol Use Disorder: A Peripheral Signature of Perineuronal Nets AlterationsDOI 10.21203/rs.3.rs-10436389/v1Read

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