Article

A novel drug-combination screen in zebrafish identifies epigenetic small molecule candidates for Duchenne muscular dystrophy

2020-02-20

Abstract excerpt

<h4>Summary</h4> Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder and is one of the most common muscular dystrophies. There are currently few effective therapies to treat the disease, although many small-molecule approaches are being pursued. Specific histone deacetylase inhibitors (HDACi) can ameliorate DMD phenotypes in mouse and zebrafish animal models and have also shown promise for DMD in...

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Literature Corpus work: 7611de3e-d3bf-5f13-8f8c-87b9c6980446
DOI: 10.1101/2020.02.19.956532

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