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Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling

13 Nov 2013

Abstract excerpt

Duchenne muscular dystrophy (DMD) is caused by a lack of the dystrophin protein and has no effective treatment at present. Zebrafish provide a powerful in vivo tool for high-throughput therapeutic drug screening for the improvement of muscle phenotypes caused by dystrophin deficiency. Using the dystrophin-deficient zebrafish, sapje, we have screened a total of 2640 compounds with known modes of action from three...

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PMID: 24234649
DOI: 10.1093/hmg/ddt579

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