Article

Gene set optimization for cancer transcriptomics using sparse principal component analysis

2025-05-26

Abstract excerpt

A common approach for exploring pathway dysregulation in cancer involves the gene set or pathway analysis of tumor transcriptomic data. Unfortunately, the effectiveness of cancer gene set testing is limited by the fact that most gene set collections model gene activity in normal tissue, which can differ significantly from gene activity found within tumors. To address this challenge, we have developed a bioinformat...

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Literature Corpus work: 75b2c908-f72b-551f-8620-011da290153d
DOI: 10.1101/2025.05.21.655279

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