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Essential Roles of the <i>SPPRA</i> Fructose-Phosphate Phosphohydrolase Operon in Carbohydrate Metabolism and Virulence Expression by <i>Streptococcus Mutans</i>

2018-06-08

Abstract excerpt

The dental caries pathogen Streptococcus mutans can ferment a variety of sugars to produce organic acids. Exposure of S. mutans to certain non-metabolizable carbohydrates such as xylitol impairs growth and can cause cell death. Recently, the presence of a sugar-phosphate stress in S. mutans was demonstrated using a mutant lacking 1-phosphofructokinase (FruK) that accumulates fructose-1-phosphate (F-1-P). Here w...

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Literature Corpus work
75a5c884-6863-581d-880b-7d78b934d687
DOI
10.1101/342170
Open publication

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