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Differential effects of loss of <i>park7</i> activity on Iron Responsive Element (IRE) gene sets: Implications for the role of iron dyshomeostasis in the pathophysiology of Parkinson’s disease

2021-03-27

Abstract excerpt

Mutation of the gene PARK7 ( DJ1 ) causes monogenic autosomal recessive Parkinson’s disease (PD) in humans. Subsequent alterations of PARK7 protein function lead to mitochondrial dysfunction, a major element in PD pathology. Homozygous mutants for the PARK7 -orthologous genes in zebrafish, park7 , show changes to gene expression in the oxidative phosphorylation pathway, supporting that disruption of energy pro...

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Literature Corpus work
75a3280a-df33-501b-ac15-f0332395b31b
DOI
10.1101/2021.03.25.437102
Open publication

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Differential effects of loss of <i>park7</i> activity on Iron Responsive Element (IRE) gene sets: Implications for the role of iron dyshomeostasis in the pathophysiology of Parkinson’s diseaseDOI 10.1101/2021.03.25.437102
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