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Transcriptome Analysis Reveals That Midnolin Regulates mRNA Expression Levels of Multiple Parkinson’s Disease Causative Genes

31 Dec 2017

Abstract excerpt

We recently found that 10.5% of sporadic Parkinson's disease (PD) patients lacked one copy of the midnolin (MIDN) gene. In addition, gene knock-down/out of MIDN caused down-regulation of parkin E3 ubiquitin ligase, indicating MIDN to be a novel PD-risk factor or causative gene. In this study, we performed RNA-sequencing and transcriptome analysis of Midn wild-type and knockout cells. Midn positively or negatively...

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PMID: 29311479
DOI: 10.1248/bpb.b17-00663

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