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Multifunctional PolySpermine-based Nanocapsules for Targeted Gene Delivery to Gastric Cancer Cells

2025-09-01

Abstract excerpt

In this study, multifunctional nanocapsules were developed and evaluated for targeted gene delivery to AGS gastric cancer cells. The design of the nanoparticles utilized hyperbranched polyspermine (HS) for efficient DNA condensation, polyethylene glycol (PEG) to increase nanoparticle stability and prolong circulation time via stealth properties, and dual-targeting ligands, i.e., folic acid and glucose, to improve...

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Identifiers and source

Literature Corpus work
759c2280-2050-56f0-86d5-a7086e52c1e7
DOI
10.1101/2025.08.27.672643
Open publication

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