X chromosomal mutations and spermatogenic failure.

doi:10.1016/j.bbadis.2012.05.012

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Article

X chromosomal mutations and spermatogenic failure.

Biochimica et biophysica acta - 1 Dec 2012

Stouffs Katrien, Lissens Willy

Abstract excerpt

The X and Y chromosomes, the sex chromosomes, are important key players in germ cell development. Both chromosomes contain genes that are uniquely expressed in male spermatogenesis. Furthermore, these chromosomes are special because men only have a single copy of them. These features make the sex chromosomes interesting for studying in view of spermatogenesis defects. The role of the Y chromosome, together with...

Topics

Animals
Comparative Genomic Hybridization
Genes, X-Linked
Genome-Wide Association Study
Humans
Mice
Mice, Knockout
Mutation
Spermatogenesis
X Chromosome
Y Chromosome

Source

Open in PubMed

Identifiers

PMID: 22634129
DOI: 10.1016/j.bbadis.2012.05.012

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