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Biotransformation and disposition of C14-labeled sonrotoclax ([14C]BGB-11417) in preclinical safety species

2025-05-08

Abstract excerpt

<h4>Background: </h4> and Purpose: Sonrotoclax (BGB-11417), a second-generation B-cell lymphoma-2 (BCL-2) inhibitor currently in clinical development, requires comprehensive verification of its biotransformation and disposition profiles in safety species. Experimental Approach: [14C]BGB-11417 was employed to assess its pharmacokinetics, excretion, tissue distribution and metabolite profiles in mice and dogs. Radio...

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Literature Corpus work
7569af34-0acf-564d-ab74-2b67dcbe1002
DOI
10.22541/au.174672755.52722319/v1
Open publication

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Biotransformation and disposition of C14-labeled sonrotoclax ([14C]BGB-11417) in preclinical safety speciesDOI 10.22541/au.174672755.52722319/v1
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