Article

A Novel Surgical Method for Continuous Intra-Portal Infusion of Gut Microbial Metabolites in Mice

2020-10-29

Abstract excerpt

Gut microbial-derived metabolites have been shown to play key roles in human physiology and disease. However, establishing mechanistic links between gut microbial metabolites and disease pathogenesis in animal models presents many challenges. The major route of absorption for microbe-derived small molecules is venous drainage via the portal vein to the liver. In the event of extensive liver first pass- or presyste...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e09c5c3e-6672-5768-97f2-79d13f3e0c71
DOI: 10.1101/2020.10.29.360628

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest

A Novel Surgical Method for Continuous Intra-Portal Infusion of Gut Microbial Metabolites in MiceDOI 10.1101/2020.10.29.360628Read

Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5Semantic proximity Read

Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse.Semantic proximity Read

High-throughput Production of Diverse Xenobiotic Metabolites with P450-transduced Huh7 Hepatoma Cell LinesSemantic proximity Read

Fecal microbial transplant abates tolerance to methylone-induced hyperthermiaSemantic proximity Read

Biotransformation and disposition of C14-labeled sonrotoclax ([14C]BGB-11417) in preclinical safety speciesSemantic proximity Read

Integrating a Microphysiological System and Physiologically Based Pharmacokinetic Modeling to Predict Human Responses to DiclofenacSemantic proximity Read

Synthesis and application of tagging agents in mass spectrometry-based targeted metabolomics studiesSemantic proximity Read

Circulating low-molecular-weight (poly)phenol metabolites in the brain: unveiling in vitro and in vivo blood–brain barrier transportSemantic proximity Read

Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized LiverSemantic proximity Read

The drug disposition in the Spleen: A novel study of CYP and UGT-mediated drug metabolismSemantic proximity Read