Article

Simulation and empirical evaluation of biologically-informed neural network performance

2025-11-14

Abstract excerpt

Biologically-informed neural networks (BiNNs) offer interpretable deep learning models for biological data, but the dataset characteristics required for strong performance remain poorly understood. For instance, we previously developed P-NET, a BiNN with an architecture based on the Reactome pathway database, and applied this model to predict metastatic status of patients with prostate cancer using somatic mutatio...

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Literature Corpus work: 75464d28-b92c-5bab-bb64-f0ea63ba1059
DOI: 10.1101/2025.11.13.687845

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