Article

A Mouse Model with Complete Penetrance for Atrioventricular Septal Defect/Complete AV Canal

2022-02-03

Abstract excerpt

Complete Atrioventricular Septal Defect/complete AV canal (AVSD/ cAVC) occurs via defective formation of the Dorsal Mesenchymal Protrusion (DMP) which grows from the interior dorsal wall of the fetal heart. The DMP is derived from cells of the second heart field (SHF). AVSD occurs in about 1/10,000 births in the general population, but is 2000 times more prevalent in individuals with Down syndrome (DS). The low pe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75378309-9ab6-58d4-9dd2-ba29ae822245
DOI: 10.1101/2022.02.03.478994

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Mouse Model with Complete Penetrance for Atrioventricular Septal Defect/Complete AV CanalDOI 10.1101/2022.02.03.478994Read

Human Genetics of Atrioventricular Septal Defect.Semantic proximity Read

The Dorsal Mesenchymal Protrusion and the Pathogenesis of Atrioventricular Septal DefectsSemantic proximity Read

Genetic aspects of atrioventricular septal defectsSemantic proximity Read

Atrioventricular canal defect and genetic syndromes: The unifying role of sonic hedgehog.Semantic proximity Read

CHD7 and retinoic acid signaling cooperate to regulate neural stem cell and inner ear development in mouse models of CHARGE syndrome.Semantic proximity Read

A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac developmentSemantic proximity Read

Development gone awry: congenital heart disease.Semantic proximity Read

The loop-tail mouse model displays open and closed caudal neural tube defects.Semantic proximity Read

Finally, a sense of closure? Animal models of human ventral body wall defectsSemantic proximity Read

Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panelSemantic proximity Read

Essential Role for ADAM19 in Cardiovascular MorphogenesisSemantic proximity Read

Animal models of congenital defects in the ventriculoarterial connection of the heart.Semantic proximity Read