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Article

Genetic aspects of atrioventricular septal defects

1 Jan 2000

Abstract excerpt

Formation of the atrioventricular canal (AVC) results from complex interactions of components of the extracellular matrix. In response to signaling molecules, endothelial/mesenchymal transformations are crucial to normal development of the AVC. Atrioventricular septal defects (AVSDs) can result from arrest or interruption of normal endocardial cushion development. The presence of AVSDs has been associated with...

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PMID: 11376440
DOI: 10.1002/1096-8628(200024)97:4<289::aid-ajmg1279>3.0.co;2-u

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