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Article

CHD7 and retinoic acid signaling cooperate to regulate neural stem cell and inner ear development in mouse models of CHARGE syndrome.

Human molecular genetics - 15 Jan 2014

Micucci Joseph A, Layman Wanda S, Hurd Elizabeth A, Sperry Ethan D, Frank Sophia F, Durham Mark A, Swiderski Donald L, Skidmore Jennifer M, Scacheri Peter C, Raphael Yehoash, Martin Donna M

Abstract excerpt

CHARGE syndrome is a multiple congenital anomaly disorder that leads to life-threatening birth defects, such as choanal atresia and cardiac malformations as well as multiple sensory impairments, that affect hearing, vision, olfaction and balance. CHARGE is caused by heterozygous mutations in CHD7, which encodes an ATP-dependent chromatin remodeling enzyme. Identification of the mechanisms underlying neurological...

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Identifiers

PMID: 24026680
DOI: 10.1093/hmg/ddt435
PMCID: PMC3869363

Genes

CHD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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CHD7 and retinoic acid signaling cooperate to regulate neural stem cell and inner ear development in mouse models of CHARGE syndrome.PMID 24026680Read ↗

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The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner earSemantic proximity Read ↗

The chromatin remodeling protein CHD7, mutated in CHARGE syndrome, is necessary for proper craniofacial and tracheal developmentSemantic proximity Read ↗

CHD7 regulates otic lineage differentiation and deafness gene expression in human inner ear organoidsSemantic proximity Read ↗

CHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expressionSemantic proximity Read ↗

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Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice.Semantic proximity Read ↗

Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues.Semantic proximity Read ↗

Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome.Semantic proximity Read ↗

CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance.Semantic proximity Read ↗

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