Article

In Silico Analysis of Mutations Along the Amyloidogenic Pathway in Alzheimer’s Disease

2024-04-15

Abstract excerpt

Through in silico simulation of mutations and their effect on protein structure, we conclusively examine the impact of mutations along the amyloidogenic pathway in three steps: as factors which undermine the suppression of A? production from BACE-1; the inhibition of amyloid breakdown by neprilysin; and the aggregation of A? monomers through oligomeric and fibril stages. We verified the significance of mutations i...

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Literature Corpus work: 30719a3a-8fd7-51e1-801b-c7449a6d637f
DOI: 10.21467/preprints.540

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