Article

Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods

2025-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Nuclear morphology is an indicator of cellular function and disease states, as changes in nuclear size, shape, and texture often reflect underlying disease-related genetic, epigenetic, and microenvironmental alterations. For disease diagnosis, nuclear segmentation performed in 2D hematoxylin and eosin (H&E)-stained tissue sections has long represented the gold standard. However, recent advances...

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Literature Corpus work: 17f42dc6-68ac-56b0-91c0-29cfc90f99ba
DOI: 10.1101/2025.03.31.646356

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