Article

Brainstem pathology in human narcolepsy: Neurodegeneration in the locus coeruleus in narcoleptic humans, but not in genetically narcoleptic mice or dogs

2025-04-18

Abstract excerpt

Our earlier study led to the conclusion that human narcolepsy with cataplexy was caused by the loss of forebrain hypocretin (orexin) neurons in the hypothalamus. We now report that humans having narcolepsy with cataplexy also have a 46% decrease in the number and an 18% increase in the size of brainstem neuromelanin-pigmented locus coeruleus (LC) neurons and increased microglial activity in LC. However, no such ch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74b89cb5-9768-56f8-b3f5-355addb19407
DOI: 10.1101/2025.04.12.648456

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brainstem pathology in human narcolepsy: Neurodegeneration in the locus coeruleus in narcoleptic humans, but not in genetically narcoleptic mice or dogsDOI 10.1101/2025.04.12.648456Read

Autoimmunity in narcolepsy.Semantic proximity Read

Greatly increased numbers of histamine cells in human narcolepsy with cataplexy.Semantic proximity Read

Narcolepsy.Semantic proximity Read

CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice.Semantic proximity Read

The Role of T Cells in the Pathogenesis of Narcolepsy Type 1: A Narrative Review.Semantic proximity Read

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.Semantic proximity Read

[Hypocretins/orexins and narcolepsy: from molecules to disease].Semantic proximity Read

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleusSemantic proximity Read

The autoimmune basis of narcolepsy.Semantic proximity Read

[Narcolepsy].Semantic proximity Read

Narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neuronsSemantic proximity Read

Sleep, sleep disorders and hypocretin (orexin).Semantic proximity Read