Article

CDK7, CDK9, or CDK11 Inhibition Reduces Neutrophil-Driven Inflammation and Tissue Damage in Experimental Autoimmune Models

2025-11-19

Abstract excerpt

<h4>Background</h4> Cyclin-dependent kinases (CDKs) are involved in basic cellular processes like regulation of cell-cycle progression and transcription. However, recent data also indicate a specific role in terminally differentiated neutrophils by promoting reactive oxygen species (ROS) release, degranulation, neutrophil extracellular trap formation, or apoptosis. Since these mechanisms are implicated in multipl...

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Literature Corpus work: 741d0b3e-27f9-549b-adee-5bb0a6619ea1
DOI: 10.1101/2025.11.19.689221

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