Article

Simultaneous CRISPR-Cas9-induced double strand breaks are lethal in models of pancreatic cancer

2023-04-05

Abstract excerpt

<h4>ABSTRACT</h4> While radiation is an effective oncologic therapy, killing cancer by inducing DNA double-strand breaks (DSBs), it lacks specificity for neoplastic cells. We have previously adapted the CRISPR-Cas9 gene-editing technology as a cancer-specific treatment modality targeting somatic mutations in pancreatic cancer (PC). However, its tumoricidal potential remains unclear, especially in comparison to th...

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Literature Corpus work: 74184db6-8843-5d26-8880-7c3a95acc24d
DOI: 10.1101/2023.04.03.535384

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