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A shared MHC immunogenetic signal connects aging, rheumatoid arthritis, and herpes zoster through chronic high inflammatory burden–compensatory immune tolerance dysregulation

2026-04-29

Abstract excerpt

Epidemiological studies connect aging and autoimmune diseases to increased herpes zoster (HZ) risk, yet their shared genetic basis remains unresolved. Here, we integrated large-scale genome-wide association studies (GWAS) of a multivariate aging latent factor (mvAge), rheumatoid arthritis (RA, representing autoimmunity), and HZ with multi-omics quantitative trait loci. Using linkage disequilibrium-aware colocaliza...

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Literature Corpus work
73fd3021-4d32-5784-bacf-d72006b21978
DOI
10.64898/2026.04.28.26351835
Open publication

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A shared MHC immunogenetic signal connects aging, rheumatoid arthritis, and herpes zoster through chronic high inflammatory burden–compensatory immune tolerance dysregulationDOI 10.64898/2026.04.28.26351835
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