Unraveling the Immune Signature of Herpes Zoster: Insights Into the Pathophysiology and Human Leukocyte Antigen Risk Profile.

doi:10.1093/infdis/jiad609

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Article

Unraveling the Immune Signature of Herpes Zoster: Insights Into the Pathophysiology and Human Leukocyte Antigen Risk Profile.

The Journal of infectious diseases - 23 Sept 2024

Vandoren Romi, Boeren Marlies, Schippers Jolien, Bartholomeus Esther, Mullan Kerry, Michels Nele, Aerts Olivier, Leysen Julie, Bervoets An, Lambert Julien, Leuridan Elke, Wens Johan, Peeters Karin, Emonds Marie-Paule, Jansens Hilde, Casanova Jean-Laurent, Bastard Paul, Suls Arvid, Van Tendeloo Viggo, Ponsaerts Peter, Delputte Peter, Ogunjimi Benson, Laukens Kris, Meysman Pieter

Abstract excerpt

The varicella-zoster virus (VZV) infects >95% of the population. VZV reactivation causes herpes zoster (HZ), known as shingles, primarily affecting the elderly and individuals who are immunocompromised. However, HZ can occur in otherwise healthy individuals. We analyzed the immune signature and risk profile in patients with HZ using a genome-wide association study across different UK Biobank HZ cohorts....

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PMID: 38195164
DOI: 10.1093/infdis/jiad609
PMCID: PMC11420803

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