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Associations of Herpes Simplex Virus Type 1/2 IgG Seropositivity and Arthritis Subtypes: Integrating Cross-Sectional Epidemiology and Genetic Association Analyses.

Genetic epidemiology - 1 Dec 2025

Li Haining, Shen Zhen, Feng Changzhou

Abstract excerpt

Herpes simplex viruses (HSV) have been detected within the synovial joint cavity, a secluded area of inflammation that may harbor etiological agents. However, the role of HSV-1/2 infection in arthritis pathogenesis remains ambiguous. In this study, we integrate cross-sectional epidemiology and genetic associations to elucidate their relationships and uncover causal mechanisms. We analyzed cross-sectional data...

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PMID: 41128443
DOI: 10.1002/gepi.70020

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