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[Autoimmunity and ageing : How immune ageing shapes disease phenotype, infection risk and treatment safety in rheumatic diseases].

Zeitschrift fur Rheumatologie - 1 Aug 2026

Leipe Jan, Schirmer Jan Henrik, Mojtaheed-Poor Sorwe

Abstract excerpt

BACKGROUND: Immune ageing alters tolerance mechanisms, the chronic low-grade inflammatory environment and host infection defence. This is clinically relevant in rheumatology because the number of older patients with inflammatory rheumatic diseases is increasing and age modifies disease phenotype, vaccination responses and treatment safety. OBJECTIVE: To summarize the interfaces between ageing, autoimmunity and...

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PMID: 42429930
DOI: 10.1007/s00393-026-01852-y

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