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Integrating Single-cell and Machine Learning with Experimental Validation Reveals FASN Conferring Breast Cancer Stem cell-like Properties: Therapeutic Insights and Prognostic Implications

2025-08-22

Abstract excerpt

<title>Abstract</title> <p>Breast cancer stem cells (BCSCs) are critical drivers of tumor recurrence, metastasis, and resistance to standard therapies, posing significant challenges in breast cancer management. Fatty acid synthase (FASN) has emerged as a key metabolic enzyme, not only supporting the lipid biosynthesis essential for tumor growth but also contributing to the maintenance of BCSC-like properties. In...

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Literature Corpus work
982fc7f2-e693-52a9-8162-d318c76f4284
DOI
10.21203/rs.3.rs-7324806/v1
Open publication

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Integrating Single-cell and Machine Learning with Experimental Validation Reveals FASN Conferring Breast Cancer Stem cell-like Properties: Therapeutic Insights and Prognostic ImplicationsDOI 10.21203/rs.3.rs-7324806/v1
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