Article

Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice

2022-10-07

Abstract excerpt

Human CD34 + hematopoietic stem and progenitor cells (HSPCs) are a standard source of cells for clinical HSC transplantations as well as experimental xenotransplantation to generate “humanized mice”. To further extend the range of applications of these humanized mice, we developed a protocol to efficiently edit the genomes of human CD34 + HSPCs before transplantation. In the past, manipulating HSPCs has been com...

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Literature Corpus work: 00933d80-cdd0-59ed-8ab7-aa41f7c1bb7b
DOI: 10.1101/2022.10.06.511235

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