Article

The 21-base pair deletion mutant Calpain 3 does not inhibit wild-type Calpain 3 activity

2023-10-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Calpain 3 is one of the calpain protease family members, which is a calcium-dependent proteolytic enzyme predominantly expressed in skeletal muscle. Loss-of-function mutations in the Calpain 3 gene have been related to autosomal recessive Limb-Girdle Muscular Dystrophy 1 (LGMDR1), a common form of muscular dystrophy. Recently, the heterozygous 21-bp deletion mutation of t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 73c611bb-b125-5332-884d-bd0d8b7ba5a6
DOI: 10.1101/2023.10.03.560718

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The 21-base pair deletion mutant Calpain 3 does not inhibit wild-type Calpain 3 activityDOI 10.1101/2023.10.03.560718Read

A heterozygous 21-bp deletion in<i>CAPN3</i>causes dominantly inherited limb girdle muscular dystrophySemantic proximity Read

Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance.Semantic proximity Read

Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice.Semantic proximity Read

Pathogenity of some limb girdle muscular dystrophy mutations can result from reduced anchorage to myofibrils and altered stability of calpain 3.Semantic proximity Read

Localization of Calpain 3 in Human Skeletal Muscle and Its Alteration in Limb-Girdle Muscular Dystrophy 2A MuscleSemantic proximity Read

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitroSemantic proximity Read

Calpains for dummies: What you need to know about the calpain family.Semantic proximity Read

An eccentric calpain, CAPN3/p94/calpain-3.Semantic proximity Read

Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families.Semantic proximity Read

Secondary reduction in calpain 3 expression in patients with limb girdle muscular dystrophy type 2B and Miyoshi myopathy (primary dysferlinopathies)Semantic proximity Read

Calpain-related diseases.Semantic proximity Read

Strategies for regulating calpain activities in living cells.Semantic proximity Read