The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes.

doi:10.1007/s00702-012-0910-z

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Article

The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes.

Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2013

Stockmann Marianne, Meyer-Ohlendorf Marie, Achberger Kevin, Putz Stefan, Demestre Maria, Yin Haishan, Hendrich Corinna, Linta Leonhard, Heinrich Jutta, Brunner Cornelia, Proepper Christian, Kuh Georges F, Baumann Bernd, Langer Torben, Schwalenstöcker Birgit, Braunstein Kerstin E, von Arnim Christine, Schneuwly Stephan, Meyer Thomas, Wong Philip C, Boeckers Tobias M, Ludolph Albert C, Liebau Stefan

Abstract excerpt

The dynactin p150glued subunit, encoded by the gene DCTN1 is part of the dynein-dynactin motor protein complex responsible for retrograde axonal transport. This subunit is a candidate modifier for neurodegenerative diseases, in particular motoneuron and extrapyramidal diseases. Based on an extensive screening effort of all 32 exons in more than 2,500 ALS/MND patients, patients suffering from Parkinsonian...

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PMID: 23143281
DOI: 10.1007/s00702-012-0910-z

Genes

DCTN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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