Article

Modulation of endothelial organelle size as an antithrombotic strategy

2020-05-17

Abstract excerpt

It is long-established that Von Willebrand Factor (VWF) is central to haemostasis and thrombosis. Endothelial VWF is stored in cell-specific secretory granules, Weibel-Palade bodies (WPBs), uniquely rod-like exocytic organelles generated in a wide range of lengths (0.5 to 5.0 µm). It has been shown that WPB size responds to physiological cues and pharmacological treatment and that, under flow, VWF secretion from s...

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Literature Corpus work: 732443f7-4d07-523f-8181-385f87166387
DOI: 10.1101/2020.05.16.099580

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