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Article

Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae

16 Jul 2015

Abstract excerpt

The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of >90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement...

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PMID: 26181911
DOI: 10.1371/journal.ppat.1005034

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