Article

The intrarenal renin-angiotensin system in hypertension: Insights from mathematical modelling

2021-12-16

Abstract excerpt

The renin-angiotensin system (RAS) plays a pivotal role in the maintenance of volume homeostasis and blood pressure. In addition to the well-studied systemic RAS, local RAS have been documented in various tissues, including the kidney. Given the role of the intrarenal RAS in the pathogenesis of hypertension, a role established via various pharmacologic and genetic studies, substantial efforts have been made to unr...

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Literature Corpus work: 7293f2f0-072a-5cd0-ad97-541c0ebf2965
DOI: 10.1101/2021.12.14.472639

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