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Article

The renin-angiotensin system and hypertension in autosomal recessive polycystic kidney disease.

Pediatric nephrology (Berlin, Germany) - 1 Dec 2010

Goto Miwa, Hoxha Nita, Osman Rania, Dell Katherine Macrae

Abstract excerpt

Hypertension is a well-recognized complication of autosomal recessive polycystic kidney disease (ARPKD). The renin-angiotensin system (RAS) is a key regulator of blood pressure; however, data on the RAS in ARPKD are limited and conflicting, showing both up- and down-regulation. In the current study, we characterized intrarenal and systemic RAS activation in relationship to hypertension and progressive cystic...

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Identifiers

PMID: 20798958
DOI: 10.1007/s00467-010-1621-z

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ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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