Article

Identification and mapping of human lymph node stromal cell subsets by combining single-cell RNA sequencing with spatial transcriptomics

2023-08-19

Abstract excerpt

<h4>Summary</h4> Lymph node stromal cells (LNSCs) have a crucial immunomodulatory function, but their heterogeneity in human is incompletely understood. Here, we report the single cell RNA sequencing (scRNA-seq) of 12’000 LNSCs isolated from a human lymph node (LN). This study comprehensively defines the gene signatures of 10 fibroblast subtypes: CCL21 + SC, CCL19 + SC, CD34 + CXCL14 + SC, pericytes, DES + S...

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Literature Corpus work: 727c8b6f-8ffc-54c1-ac0b-a6f6cf32ae6f
DOI: 10.1101/2023.08.18.553530

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