Article

SARS-CoV-2 spike-specific memory B cells express markers of durable immunity after non-severe COVID-19 but not after severe disease

2021-09-27

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 infection elicits a robust B cell response, resulting in the generation of long-lived plasma cells and memory B cells. Here, we aimed to determine the effect of COVID-19 severity on the memory B cell response and characterize changes in the memory B cell compartment between recovery and five months post-symptom onset. Using high-parameter spectral flow cytometry, we analyzed the pheno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a6de2bd-0666-58c6-b847-6ee88a48ac69
DOI: 10.1101/2021.09.24.461732

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 spike-specific memory B cells express markers of durable immunity after non-severe COVID-19 but not after severe diseaseDOI 10.1101/2021.09.24.461732Read

SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe diseaseSemantic proximity Read

SARS-CoV-2 Infection Generates Long-Lived Memory B Cells Against the Receptor Binding Domain of the Spike ProteinSemantic proximity Read

COVID-19 Infection Induces Substantial Memory B Cell Maturation to Non-Neutralizing Viral TargetsSemantic proximity Read

Longitudinal characterization of humoral and cellular immunity in hospitalized COVID-19 patients reveal immune persistence up to 9 months after infectionSemantic proximity Read

Rapid and lasting generation of B-cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 disease and convalescenceSemantic proximity Read

Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cellsSemantic proximity Read

'One Year Later' - SARS-CoV-2-Specific Immunity in Mild Cases of COVID-19Semantic proximity Read

Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cellsSemantic proximity Read

Maturation and persistence of the anti-SARS-CoV-2 memory B cell responseSemantic proximity Read

Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19Semantic proximity Read

High titre neutralizing antibodies in response to SARS-CoV-2 infection require RBD-specific CD4 T cells that include proliferative memory cellsSemantic proximity Read

Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike proteinSemantic proximity Read