Article

Rapid and lasting generation of B-cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 disease and convalescence

2020-11-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Lasting immunity to SARS-CoV-2 following infection is questioned because serum antibodies decline in convalescence. However, functional immunity is mediated by long-lived memory T and B (Bmem) cells. <h4>Objective</h4> To determine the longevity and immunophenotype of SARS-CoV-2-specific Bmem cells in COVID-19 patients. <h4>Methods</h4> Recombinant spike receptor binding domai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0faaadb2-5ca1-5de1-bf1c-21b2a22882a5
DOI: 10.1101/2020.11.17.20233544

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid and lasting generation of B-cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 disease and convalescenceDOI 10.1101/2020.11.17.20233544Read

Longitudinal characterization of humoral and cellular immunity in hospitalized COVID-19 patients reveal immune persistence up to 9 months after infectionSemantic proximity Read

Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cellsSemantic proximity Read

SARS-CoV-2 Infection Generates Long-Lived Memory B Cells Against the Receptor Binding Domain of the Spike ProteinSemantic proximity Read

'One Year Later' - SARS-CoV-2-Specific Immunity in Mild Cases of COVID-19Semantic proximity Read

COVID-19 Infection Induces Substantial Memory B Cell Maturation to Non-Neutralizing Viral TargetsSemantic proximity Read

SARS-CoV-2 spike-specific memory B cells express markers of durable immunity after non-severe COVID-19 but not after severe diseaseSemantic proximity Read

Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cellsSemantic proximity Read

Maturation and persistence of the anti-SARS-CoV-2 memory B cell responseSemantic proximity Read

Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike proteinSemantic proximity Read

Persistence of Functional Memory B Cells Recognizing SARS-CoV-2 Variants Despite Loss of Specific IgGSemantic proximity Read

S protein-reactive IgG and memory B cell production after human SARS-CoV-2 infection includes broad reactivity to the S2 subunitSemantic proximity Read

High titre neutralizing antibodies in response to SARS-CoV-2 infection require RBD-specific CD4 T cells that include proliferative memory cellsSemantic proximity Read