Article

Timing antigenic escape in multiple myeloma treated with T-cell redirecting immunotherapies

2024-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Recent data highlight genomic events driving antigen escape as a recurring cause of chimeric antigen receptor T-cell (CAR-T) and bispecific T-cell engager (TCE) resistance in multiple myeloma (MM). Yet, it remains unclear if these events, leading to clonal dominance at progression, result from acquisition under treatment selection or selection of pre-existing undetectable clones. This differenti...

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Literature Corpus work: 71f68e9f-7a16-597c-9e64-e9e53edf83b6
DOI: 10.1101/2024.05.22.595383

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