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Article

Acquired and Selected: Tracking Antigen Escape during T Cell-Redirecting Therapies in Multiple Myeloma.

Blood cancer discovery - 3 Nov 2025

Kauer Joseph, Weinhold Niels, Raab Marc S

Abstract excerpt

In this issue of Blood Cancer Discovery, Papadimitriou and colleagues implement a temporal workflow to monitor genomic antigen escape during BCMA- or GPRC5D-directed immunotherapy. Using chemotherapy-induced mutational signatures as barcodes, they provide evidence that these mutations are acquired during therapy rather than being preexisting in newly diagnosed patients. See related article by Papadimitriou et...

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Source

Identifiers

PMID: 41081656
DOI: 10.1158/2643-3230.BCD-25-0328

Genes

GPRC5D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acquired and Selected: Tracking Antigen Escape during T Cell-Redirecting Therapies in Multiple Myeloma.PMID 41081656Read ↗

Timing antigenic escape in multiple myeloma treated with T-cell redirecting immunotherapiesSemantic proximity Read ↗

Timing Genomic Antigen Loss in Multiple Myeloma Treated with T Cell-Redirecting Immunotherapies.Semantic proximity Read ↗

Multi-Omic Profiling Reveals Epigenetic Drivers of Immunotherapy Resistance in Multiple MyelomaSemantic proximity Read ↗

Designing Evolutionary-based Interception Strategies to Block the Transition from Precursor Phases to Multiple Myeloma.Semantic proximity Read ↗

Single- and double-hit events in genes encoding immune targets before and after T cell–engaging antibody therapy in MMSemantic proximity Read ↗

Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine.Semantic proximity Read ↗

A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myelomaSemantic proximity Read ↗

Deciphering response dynamics and treatment resistance from circulating tumor DNA after CAR T-cells in multiple myelomaSemantic proximity Read ↗

Accelerated single cell seeding in relapsed multiple myeloma.Semantic proximity Read ↗

Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivationSemantic proximity Read ↗

Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencingSemantic proximity Read ↗

Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma.Semantic proximity Read ↗

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