Article

The influence of marker number and sequencing depth on the ability to identify mismatch repair deficient tumours

2023-07-19

Abstract excerpt

1. Analysis of somatic mutation patterns is widely used to infer exposure to exogenous and endogenous mutagenic influences. This raises the question of the amount of sequence data required to detect factors of interest. A common use of mutation pattern analysis is the identification of increased microsatellite instability to uncover mismatch repair (MMR) defects in tumours and normal tissues. Here we explore the e...

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Literature Corpus work: 71f4ef49-4cab-53bb-bc53-ada5a2629d5c
DOI: 10.1101/2023.07.18.546679

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