Article

Accelerated Biological Aging in Familial Pulmonary Fibrosis

2024-10-11

Abstract excerpt

Since Familial Pulmonary Fibrosis (FPF) manifests in older adults and telomere attrition is common in FPF and sporadic Idiopathic Pulmonary Fibrosis (IPF), we postulated that accelerated aging, as determined by epigenetic clock (DNA methylation) measurements, could occur in FPF. We measured DNAge from blood of patients with FPF and a group of first-degree relatives of FPF patients without disease (termed “at-risk”...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 719472a6-ff51-5db5-8a49-4fe15be62e4e
DOI: 10.1101/2024.10.10.24315235

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Accelerated Biological Aging in Familial Pulmonary FibrosisDOI 10.1101/2024.10.10.24315235Read

Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocksSemantic proximity Read

Telomere Integrity, Epigenetic Aging, and Genetic Burden Shape Biological Aging Trajectories in Idiopathic Pulmonary FibrosisSemantic proximity Read

Age-dependent Genetic Risk in Pulmonary Fibrosis Patients and RelativesSemantic proximity Read

DNA Methylation-Based Age Prediction and Telomere Length Reveal an Accelerated Aging in Induced Sputum Cells Compared to Blood Leukocytes: A Pilot Study in COPD PatientsSemantic proximity Read

Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies.Semantic proximity Read

Heterozygous RTEL1 mutations are associated with familial pulmonary fibrosis.Semantic proximity Read

GWAS of epigenetic ageing rates in blood reveals a critical role for <i>TERT</i>Semantic proximity Read

GWAS of epigenetic aging rates in blood reveals a critical role for TERTSemantic proximity Read

Association between advanced fibrosis and epigenetic age acceleration among individuals with MASLDSemantic proximity Read

Natural history of pulmonary fibrosis in two subjects with the same telomerase mutation.Semantic proximity Read

Epigenetic age and lung cancer risk in the CLUE II prospective cohort studySemantic proximity Read

EPIGENETIC AGE ACCELERATION, LUNG FUNCTION AND COPD ACROSS THE LIFESPANSemantic proximity Read